NAFLD Fibrosis Score (NFS)
NFS and FIB-4 are validated non-invasive tools to identify advanced liver fibrosis in NAFLD, reducing the need for liver biopsy.
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NFS < -1.455: low risk NFS > 0.676: high risk Use with FIB-4 for best accuracy
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Why: Advanced fibrosis (F3-F4) predicts cirrhosis and liver-related outcomes. Non-invasive scores help stratify who needs further testing.
How: Enter age, BMI, diabetes status, AST, ALT, platelets, albumin. NFS and FIB-4 formulas combine these into risk categories.
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🟢 Low Risk
Normal liver enzymes, no diabetes
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🟡 Intermediate
Elevated enzymes, prediabetes
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🔴 High Risk
Diabetic with elevated AST/ALT
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🏋️ Obese NAFLD
Metabolic syndrome
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📊 Lean NAFLD
Normal BMI with NAFLD
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For informational purposes only — not medical advice. Consult a healthcare professional before acting on results.
🏥 Health Facts
Non-invasive fibrosis assessment
— Clinical
Validated in NAFLD
— Research
Understanding NAFLD Fibrosis Scoring
The NAFLD Fibrosis Score (NFS) and FIB-4 are validated non-invasive tools to identify patients with advanced fibrosis (F3-F4), reducing the need for liver biopsy.
Low Risk
NFS < -1.455
FIB-4 < 1.3
Advanced fibrosis unlikely
Intermediate
NFS -1.455 to 0.676
FIB-4 1.3 to 2.67
Further testing needed
High Risk
NFS > 0.676
FIB-4 > 2.67
Advanced fibrosis likely
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