Pg:E2 Ratio
Shedding phase, low hormones
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Evidence-based calculations Used in clinical settings worldwide Regular monitoring recommended
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✅ Healthy Mid-Luteal
Day 21, optimal for implantation
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⚠️ Estrogen Dominance
Low progesterone, PMS symptoms
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📉 Both Low
Possible anovulation
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🤰 Early Pregnancy
Rising progesterone supports pregnancy
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👵 Perimenopause
Fluctuating hormones
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Enter Hormone Values
For informational purposes only — not medical advice. Consult a healthcare professional before acting on results.
🏥 Health Facts
— WHO
— CDC
Understanding Progesterone:Estrogen Ratio
The Pg:E2 ratio reflects the balance between progesterone and estrogen. During the luteal phase, adequate progesterone relative to estrogen is essential for endometrial support, cycle regularity, and reducing PMS symptoms.
Estrogen Dominant
Ratio <100: PMS, heavy periods, breast tenderness
Optimal Balance
Ratio 200-300: Ideal luteal phase support
Progesterone Dominant
Ratio >500: Pregnancy or supplementation
Cycle Phase Reference
| Phase | Days | Progesterone Range | Estradiol Range | Expected Ratio |
|---|---|---|---|---|
| Menstrual | 1-5 | 0.1-0.7 ng/mL | 20-50 pg/mL | 2-35 |
| Early Follicular | 6-10 | 0.1-0.9 ng/mL | 30-100 pg/mL | 1-30 |
| Late Follicular | 11-13 | 0.1-1.5 ng/mL | 100-400 pg/mL | 0.25-15 |
| Ovulatory | 14 | 0.5-3 ng/mL | 150-500 pg/mL | 1-20 |
| Early Luteal | 15-18 | 2-12 ng/mL | 50-180 pg/mL | 20-200 |
| Mid-Luteal | 19-23 | 5-25 ng/mL | 50-200 pg/mL | 50-500 |
| Late Luteal | 24-28 | 2-15 ng/mL | 40-150 pg/mL | 20-300 |
Signs of Hormone Imbalance
Estrogen Dominance Symptoms
- • Heavy, painful periods
- • Breast tenderness & swelling
- • Mood swings, anxiety, irritability
- • Bloating & water retention
- • Weight gain (hips, thighs)
- • Fibroids & endometriosis
- • Headaches before period
Low Progesterone Symptoms
- • Short luteal phase (<10 days)
- • Spotting before period
- • Difficulty staying pregnant
- • Anxiety and poor sleep
- • Low libido
- • Hot flashes (perimenopause)
- • Irregular cycles
Optimizing Your Pg:E2 Ratio
🥗 Nutrition
- • Cruciferous vegetables for estrogen metabolism
- • Healthy fats (avocado, olive oil, nuts)
- • Zinc-rich foods (pumpkin seeds, oysters)
- • Vitamin B6 (poultry, fish, potatoes)
- • Fiber to eliminate excess estrogen
🏃 Lifestyle
- • Manage stress (lowers cortisol steal)
- • 7-9 hours quality sleep
- • Moderate exercise (not excessive)
- • Maintain healthy body weight
- • Reduce xenoestrogen exposure
💊 Supplements (discuss with provider)
- • Vitex (Chasteberry) for progesterone
- • DIM for estrogen metabolism
- • Magnesium for hormone balance
- • Vitamin D for overall health
- • Calcium D-Glucarate for detox
Frequently Asked Questions
What is a good progesterone level on Day 21?
Mid-luteal progesterone (day 21 of a 28-day cycle) should be at least 5 ng/mL to confirm ovulation, with optimal levels around 10-25 ng/mL for conception.
Can estrogen dominance cause infertility?
Yes, estrogen dominance (low Pg:E2 ratio) can thin the uterine lining, disrupt implantation, and shorten the luteal phase, making it harder to conceive or maintain pregnancy.
When should I test my hormones?
For luteal assessment, test on Day 21 (or 7 days post-ovulation). For follicular/baseline, test on Day 3. Testing timing matters significantly for interpretation.
What causes low progesterone?
Common causes include anovulation, stress (cortisol steal), thyroid dysfunction, PCOS, perimenopause, excessive exercise, and nutrient deficiencies (B6, zinc, vitamin C).
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