Albumin Globulin Ratio
Severely reversed A/G ratio
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Evidence-based calculations Used in clinical settings worldwide Regular monitoring recommended
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Why: This calculation helps assess important health parameters for clinical and personal wellness tracking.
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✅ Normal Healthy Adult
Routine labs showing normal A/G ratio
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🟡 Liver Cirrhosis
Cirrhosis with low albumin and reversed ratio
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⚠️ Multiple Myeloma Suspect
Elderly with elevated globulins, bone pain
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💧 Nephrotic Syndrome
Significant proteinuria with low albumin
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🦠 Chronic Infection
Chronic hepatitis with hyperglobulinemia
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🔬 Autoimmune Disease
SLE patient with polyclonal gammopathy
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🍽️ Malnutrition
Elderly with poor nutritional intake
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🛡️ Immunodeficiency
Recurrent infections with low globulins
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🧪 Lab Values
📋 Medical History
🔬 Additional Labs (Optional)
For informational purposes only — not medical advice. Consult a healthcare professional before acting on results.
🏥 Health Facts
— WHO
— CDC
What is A/G Ratio?
The Albumin/Globulin (A/G) ratio compares two major protein groups in the blood. Albumin, made by the liver, maintains oncotic pressure and transports substances. Globulins include immunoglobulins (antibodies), transport proteins, and enzymes. The A/G ratio helps assess liver function, kidney function, nutritional status, and immune system activity.
Albumin
Made by liver; maintains oncotic pressure, transports hormones, drugs, and nutrients. Low in liver/kidney disease.
Globulins
Include antibodies (immunoglobulins), transport proteins, enzymes. Elevated in infections, autoimmune disease, myeloma.
The Ratio
Normal A/G ratio is 1.1-2.5. Low ratio suggests liver disease, inflammation, or myeloma. High ratio may indicate immunodeficiency.
Protein Fractions Reference
| Fraction | Normal Range | Function | Elevated In |
| Albumin | 3.5-5.0 g/dL | Oncotic pressure, transport | Dehydration |
| Alpha-1 Globulins | 0.1-0.3 g/dL | Protease inhibitors | Acute inflammation |
| Alpha-2 Globulins | 0.6-1.0 g/dL | Transport proteins | Nephrotic syndrome, Inflammation |
| Beta Globulins | 0.7-1.2 g/dL | Complement, transferrin | Iron deficiency, Hyperlipidemia |
| Gamma Globulins | 0.7-1.6 g/dL | Immunoglobulins (antibodies) | Chronic infections, Autoimmune |
Clinical Significance of A/G Ratio
Low A/G Ratio (<1.0)
- • Liver cirrhosis (decreased albumin synthesis)
- • Nephrotic syndrome (albumin loss in urine)
- • Multiple myeloma (monoclonal gammopathy)
- • Chronic infections (polyclonal gammopathy)
- • Autoimmune diseases
High A/G Ratio (>2.5)
- • Hypogammaglobulinemia
- • Primary immunodeficiency
- • Selective IgA deficiency
- • Dehydration (relative increase)
- • Protein-losing enteropathy (globulin loss)
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