MEDICALMedication DosingHealth Calculator
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I V I G Dose

Immune Thrombocytopenic Purpura

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Evidence-based calculations Used in clinical settings worldwide Regular monitoring recommended

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Why: This calculation helps assess important health parameters for clinical and personal wellness tracking.

How: Enter your values above and the calculator will apply validated formulas to compute your results.

Evidence-based calculationsUsed in clinical settings worldwide
Sources:Medical LiteratureWHO Guidelines

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Understanding I V I G DoseUse the calculator below to check your health metrics

💉 Primary Immunodeficiency - Adult

45-year-old male with CVID requiring monthly replacement therapy at 0.4 g/kg

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🩸 ITP - Obese Patient

55-year-old female with severe ITP, BMI 38, using adjusted body weight dosing

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⚡ Guillain-Barré Syndrome - Acute

32-year-old male with rapidly progressive GBS requiring urgent IVIG treatment

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🧠 CIDP - Induction Therapy

60-year-old male with CIDP starting induction therapy at 2 g/kg over 5 days

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👶 Kawasaki Disease - Pediatric

4-year-old child with Kawasaki disease requiring single high-dose IVIG infusion

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Patient Information

Patient Demographics

Patient height for IBW calculation
Current body weight
Patient age in years
Biological sex for IBW calculation

Clinical Parameters

Select indication to auto-populate dose
IVIG dose per kilogram body weight
Number of days to split the total dose

Patient Risk Factors

Kidney function affects IVIG clearance
Heart function affects fluid tolerance
History of adverse reactions to IVIG

Infusion Settings

Product concentration
Maximum infusion rate if tolerated

For informational purposes only — not medical advice. Consult a healthcare professional before acting on results.

🏥 Health Facts

— WHO

— CDC

What is IVIG and How is it Dosed?

Intravenous Immunoglobulin (IVIG) is a blood product containing pooled IgG antibodies from thousands of donors. It is used to treat immune deficiencies, autoimmune disorders, and inflammatory conditions. Proper dosing based on adjusted body weight is critical for efficacy and safety.

Adjusted Body Weight

For obese patients (BMI ≥30), dosing uses adjusted body weight to prevent overdosing while maintaining efficacy.

Formula:

ABW = IBW + 0.4 × (Actual - IBW)

Indication-Based Dosing

Doses vary significantly by condition, from 0.4 g/kg monthly for immunodeficiency to 2 g/kg for acute conditions.

Common Doses:

  • PID: 0.4-0.6 g/kg monthly
  • ITP: 1 g/kg × 2 days
  • GBS: 0.4 g/kg × 5 days

Safety Considerations

IVIG carries risks of thrombosis, renal failure, and infusion reactions requiring careful patient selection.

Risk Factors:

  • Renal impairment
  • Cardiac disease
  • Previous reactions

How IVIG Dosing Works

Step-by-Step Dosing Process

  1. 1Calculate Ideal Body Weight (IBW) using Devine formula
  2. 2For BMI ≥30, calculate Adjusted Body Weight
  3. 3Multiply dosing weight by indication-specific dose (g/kg)
  4. 4Round total dose to nearest 5g for practical dispensing
  1. 5Divide dose across infusion days if appropriate
  2. 6Calculate infusion volume based on concentration
  3. 7Determine infusion rate starting at 0.5 mL/kg/hr
  4. 8Titrate rate as tolerated to maximum safe rate

When to Use IVIG Therapy

Immune Deficiencies

  • • Primary immunodeficiency (CVID, XLA)
  • • Secondary immunodeficiency
  • • Hypogammaglobulinemia

Autoimmune Disorders

  • • Immune thrombocytopenia (ITP)
  • • Guillain-Barré syndrome
  • • Myasthenia gravis crisis

Inflammatory Conditions

  • • Kawasaki disease
  • • CIDP
  • • Multifocal motor neuropathy

IVIG Dosing Formulas

Ideal Body Weight (Devine Formula)

Males: IBW (kg) = 50 + 2.3 × (height in inches - 60)

Females: IBW (kg) = 45.5 + 2.3 × (height in inches - 60)

Adjusted Body Weight

ABW = IBW + 0.4 × (Actual Weight - IBW)

Used when BMI ≥ 30 or actual weight exceeds IBW significantly

Total IVIG Dose

Total Dose (g) = Dosing Weight (kg) × Dose (g/kg)

Rounded to nearest 5g for practical dispensing

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