I V I G Dose
Immune Thrombocytopenic Purpura
Why This Health Metric Matters
Why: This calculation helps assess important health parameters for clinical and personal wellness tracking.
How: Enter your values above and the calculator will apply validated formulas to compute your results.
- ●Evidence-based calculations
- ●Used in clinical settings worldwide
- ●Regular monitoring recommended
Sample Clinical Scenarios
💉 Primary Immunodeficiency - Adult
45-year-old male with CVID requiring monthly replacement therapy at 0.4 g/kg
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🩸 ITP - Obese Patient
55-year-old female with severe ITP, BMI 38, using adjusted body weight dosing
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⚡ Guillain-Barré Syndrome - Acute
32-year-old male with rapidly progressive GBS requiring urgent IVIG treatment
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🧠 CIDP - Induction Therapy
60-year-old male with CIDP starting induction therapy at 2 g/kg over 5 days
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👶 Kawasaki Disease - Pediatric
4-year-old child with Kawasaki disease requiring single high-dose IVIG infusion
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Patient Information
Patient Demographics
Clinical Parameters
Patient Risk Factors
Infusion Settings
⚠️For informational purposes only — not medical advice. Consult a healthcare professional before acting on results.
🏥 Health Facts
— WHO
— CDC
What is IVIG and How is it Dosed?
Intravenous Immunoglobulin (IVIG) is a blood product containing pooled IgG antibodies from thousands of donors. It is used to treat immune deficiencies, autoimmune disorders, and inflammatory conditions. Proper dosing based on adjusted body weight is critical for efficacy and safety.
Adjusted Body Weight
For obese patients (BMI ≥30), dosing uses adjusted body weight to prevent overdosing while maintaining efficacy.
Formula:
ABW = IBW + 0.4 × (Actual - IBW)
Indication-Based Dosing
Doses vary significantly by condition, from 0.4 g/kg monthly for immunodeficiency to 2 g/kg for acute conditions.
Common Doses:
- PID: 0.4-0.6 g/kg monthly
- ITP: 1 g/kg × 2 days
- GBS: 0.4 g/kg × 5 days
Safety Considerations
IVIG carries risks of thrombosis, renal failure, and infusion reactions requiring careful patient selection.
Risk Factors:
- Renal impairment
- Cardiac disease
- Previous reactions
How IVIG Dosing Works
Step-by-Step Dosing Process
- 1Calculate Ideal Body Weight (IBW) using Devine formula
- 2For BMI ≥30, calculate Adjusted Body Weight
- 3Multiply dosing weight by indication-specific dose (g/kg)
- 4Round total dose to nearest 5g for practical dispensing
- 5Divide dose across infusion days if appropriate
- 6Calculate infusion volume based on concentration
- 7Determine infusion rate starting at 0.5 mL/kg/hr
- 8Titrate rate as tolerated to maximum safe rate
When to Use IVIG Therapy
Immune Deficiencies
- • Primary immunodeficiency (CVID, XLA)
- • Secondary immunodeficiency
- • Hypogammaglobulinemia
Autoimmune Disorders
- • Immune thrombocytopenia (ITP)
- • Guillain-Barré syndrome
- • Myasthenia gravis crisis
Inflammatory Conditions
- • Kawasaki disease
- • CIDP
- • Multifocal motor neuropathy
IVIG Dosing Formulas
Ideal Body Weight (Devine Formula)
Males: IBW (kg) = 50 + 2.3 × (height in inches - 60)
Females: IBW (kg) = 45.5 + 2.3 × (height in inches - 60)
Adjusted Body Weight
Used when BMI ≥ 30 or actual weight exceeds IBW significantly
Total IVIG Dose
Rounded to nearest 5g for practical dispensing